College football picks, schedule: Predictions vs. the spread, odds for top 25 games in Week 5 – CBS Sports

College football picks, schedule: Predictions vs. the spread, odds for top 25 games in Week 5 - CBS Sports

It went by quickly but the 2022 college football season is about a third over and the rankings are settling down as we get deeper into the campaign. And the schedule for Week 5 offers plenty of terrific top-25 contests with implications across Power Five and Group of Five conferences and the College Football Playoff picture. Even better, these showdowns are spread throughout the day on Saturday, giving fans the chance to tune in as many as possible throughout the day.

In fact, there are five games between ranked opponents on the day with two such contests each between SEC and ACC opponents. No. 14 Ole Miss hosts No. 7 Kentucky as a touchdown favorite despite its higher ranking, while No. 2 Alabama hits the road at No. 20 Arkansas as a 17-point favorite, according to Caesars Sportsbook. No. 23 Florida State looks to remain undefeated with a home tilt against No. 22 Wake Forest before No. 5 Clemson and No. 10 NC State meet as top-10 undefeated in a prime-time showcase. Don’t be left out, No. 16 Baylor aims to jump back to the top of the Big 12 race when it hosts undefeated No. 9 Oklahoma State.

When Saturday’s action is over, the top 25 will look notably different, and there may even be major changes to the CFP projections. (Although there are two games scheduled for Sunday with Sunshine State teams that had to postpone their kickoffs because of Hurricane Ian, neither have ranked programs.)

Be sure to stay with CBS Sports throughout the day for college football coverage from kickoff onward. Let’s take a look at our expert picks for the best games in Week 5.


Odds via Caesars Sportsbook | Always eastern

#10 NC State at #5 Clemson

Outstanding Game | Clemson Tigers vs. NC State Wolfpack


19:30 | ESPN, fuboTV (Try for free) — I’ll take Clemson straight up, but give me NC State pickup points on the road. Clemson will win the battle at the line of scrimmage and force some mistakes from Devin Leary that will keep this from becoming a shootout. Tigers running back Will Shipley will take over late and prevent DJ Uiagalelei from having to be a difference maker for the second straight week. This one will come down to the final drive or two, and the Tigers will be out to keep their national championship hopes alive. Prediction: NC State +6.5 — Barrett Sallee


Which college football picks can you make with confidence in Week 5, and which 10 favorite will go down? Visit SportsLine to see which teams will win and cover the spread — all from a proven computer model that has returned more than $3,100 in profit over the past six plus seasons — and find out.

#4 Michigan at Iowa

Outstanding Game | Iowa Hawkeyes vs. Michigan Wolverines


Noon | fox, fuboTV (Try for free) — When these teams met last December in the Big Ten Championship Game, Michigan soundly defeated Iowa, 42-3. The jury is out on whether the Wolverines are as good as last season, but Iowa appears to have regressed. The Hawkeyes have scored just four offensive touchdowns in four games and now face an opponent that is far superior to any they’ve seen yet. Michigan gave up four touchdown drives of 70 yards or more in a 34-27 win over Maryland last week, but the Terrapins are far better equipped offensively than Iowa. Even if the Hawkeyes manage to slow down Michigan’s offense, it’s hard to see them reaching double digits without some ridiculous turnover fortune. The Wolverines should cover this spread with any score in the 20s. Prediction: Michigan -10.5 — David Cobb

#7 Kentucky at #14 Ole Miss

Outstanding Game | Ole Miss Rebels vs. Kentucky Wildcats


Noon | ESPN, fuboTV (Try for free) — The Rebels are heavy favorites heading into the matchup despite a lower ranking. However, don’t count the Wildcats out. Kentucky boasts significant defensive upside, along with more experience at the quarterback position. Ole Miss’ offensive reputation under coach Lane Kiffin is well established, but Jaxson Dart hasn’t been tested against a quality defense. That will change this week. Prediction: Kentucky +7 — Shehan Jeyarajah

#2 Alabama at #20 Arkansas


15:30 | CBS, CBSSports.com, CBS Sports AppPart of the reason Alabama hasn’t been good on the road is that its offensive line hasn’t been up to the typical standard. This year’s Alabama offense hasn’t been nearly as explosive in the passing game as we’ve seen in recent years. There is no true alpha receiver — at least not one who has taken the reins from the outstanding receivers Alabama has had on its roster. All of that combined with Arkansas dropping into coverage and forcing teams to put together long drives to beat it suggests this will be a lower, closer affair than anticipated. I don’t have high confidence in it, but if I’m betting anything here, I’d rather be on the Razorbacks. Prediction: Arkansas +17 – Tom Fornelli

#9 Oklahoma State at #16 Baylor

Outstanding Game | Baylor Bears vs. Oklahoma State Cowboys


15:30 | fox, fuboTV (Try for free) — Oklahoma State has won the last two regular-season matchups between these teams, but the Cowboys haven’t been tested in 2022 since losing defensive coordinator Jim Knowles to Ohio State. The Bears maintained their impressive defensive performance and showed a real edge in the passing game in a win over Iowa State. Home field advantage carries the day. Prediction: Baylor -2.5 — Shehan Jeyarajah

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